Findings confirmed that PAFAH1B3 had a moderate accuracy (AUC > 0.75) in predicting BLCA, BRCA, CHOL, COAD, ESCA, GBM, HNSC, KICH, KIRP, LAML, LGG, LIHC, LUAD, LUSC, OV, PAAD, PRAD, THCA, THYM, and UCS, confirming that PAFAH1B3 has the potential to act as a detection index for the diagnosis of diverse cancers. The gene discussed is PAFAH1B3; the disease is cancer.