CD44 and central nervous system cancer: Furthermore, CD44 transcription level is related to M2 macrophage infiltration at bulk-seq resolution (Figure 5B), and this finding is verified by single-cell RNA-seq data that CD44+ TAMs are in M2-type state (Figure 9E) and by IHC that glioma with higher CD44+ cells infiltration has more infiltrating M2 macrophages (Figure 10A).