CD44 takes part in formation and persistence of regulatory T cells which play a vital role in tumor immunosuppression: LGALS9 interacts with CD44 in association with TGF-β receptors to drive FOXP3 expression in regulatory T cells (66); CD44 maintains FOXP3+ regulatory T cell persistence via inducing production of IL10 and TGFB1 (67). Here, LGALS9 is linked to neoplasm.