In addition, we calculated the Pearson's correlated genes with CD44 in CD44+ tumor cells and uncovered that some positive related genes are immunosuppressive genes (e.g., C10orf54, TGFB1, VEGFA, HAVCR2, and IDO1) and that some negative related genes are immune stimulator genes (e.g., BTN3A2, BTN3A1, TNFSF9, TNF, TNFSF4, IL1A, IL12A, TNFRSF4, CD27, TNFRSF9, CD40, TLR4, HMGB1, and ENTPD1) (Figure 9J, Supplementary Table 8). The gene discussed is HMGB1; the disease is neoplasm.