An anti-inflammatory role for IL-38 has been demonstrated in a humanized allergic asthma NOD/SCID murine model, showing that IL-38 inhibits proinflammatory cytokines (IL-6, TNF, CCL5, and CXCL10), probably via the classical STAT1, STAT3, p38 MAPK, ERK1/2, and NF-κB pathways (22). The gene discussed is IL1F10; the disease is allergic asthma.