Zhan et al. observed that a high-glucose environment induced a decreased PINK1/Parkin expression, LC3, and mitophagy in renal tubular epithelial cells in Streptozotocin (STZ)-induced DN mice, which caused mitochondrial ROS (mROS) overproduction, mitochondrial fission, and apoptosis (37). Here, PRKN is linked to liver dysplastic nodule.