Multinomial logistic regression analysis showed that prenatal first SBP (HR = 3.490, 95% CI 1.539–7.915, p = 0.003), TC (HR = 3.582, 95% CI 1.599–8.020, p = 0.002), BNP (HR = 9.167, 95% CI 3.737–22.486, p < 0.001) were independent risk factors for severe preeclampsia (Table 3). The gene discussed is NPPB; the disease is preeclampsia.