In addition, hesperidin attenuates BLM-induced lung toxicity by inhibiting the IκBα/NF-κB pathway, which in turn improves the regulation of oxidative inflammatory markers (Nrf2 and HO-1) and pro-inflammatory markers (TNF-α, IL-1β, and IL-6) to reduce collagen deposition during pulmonary fibrosis (Zhou Z et al., 2019). The gene discussed is NFKB1; the disease is pulmonary fibrosis.