NFE2L2 and acute liver failure: Among them, corilagin and farrerol, the common hepatoprotective preconditioners, can effectively protect liver cells from APAP-induced acute liver failure (ALF) by activating Nrf2 or upregulating the AMPK/GSK3β-Nrf2 signaling pathway, which in turn is involved in the prevention of hepatotoxicity (Wang et al., 2019a; Lv et al., 2019).