Mechanically, there was a complementary sequence in circRNA-ZFR for miR-16, and miR-16 could target the 3′-untranslated region of MAPK1 (mitogen-activated protein kinase 1); as a member of the MAPK family, MAPK1 is well known as an oncogene that is activated or highly expressed in various types of human cancer (Jiang et al., 2019; Deng et al., 2020; Janardhan et al., 2020). This evidence concerns the gene MAPK1 and cancer.