As an important regulatory molecule of glucose metabolism (Zhang W. Y. et al., 2019; Unachukwu et al., 2020; Wu et al., 2020), HMGA2 (high mobility group AT-hook 2) was proved to be a downstream target gene of miR-375 involved in the regulation of HCC progression. This evidence concerns the gene HMGA2 and hepatocellular carcinoma.