NRF1 and Insulin resistance: Notably, multiple studies have demonstrated an association of NRF1 dysregulation with insulin resistance and type two diabetes (Patti et al., 2003; Cho et al., 2005) as well as autism and schizophrenia (McMeekin et al., 2016), clinical features frequently observed in patients with low- and high-grade X aneuploid patients (Visootsak et al., 2007; Gropman et al., 2010; Cederlöf et al., 2014).