PLEKHO1 and cardiac hypertrophy: In cardiac-specific Ckip-1 3′-UTR overexpression under Ckip-1 knockout background (Ckip-1 KO/3′-UTR TG) mice, Ckip-1 3′-UTR inhibits pathological cardiac hypertrophy independently of its cognate protein by fatty acid metabolism pathway (Zhao et al., 2021).