In colorectal cancer cells, the KDM4B protein was found to interact with TCF4, β-catenin and ERG1 (sequence-specific transcription factor ETs-related gene 1), thereby promoting downstream expression of Jun, MYC, Cyclin D1, and TCL (the small GTPase TC10-like) (Berry et al., 2014; Chen et al., 2021). The gene discussed is KDM4B; the disease is colorectal cancer.