Yang et al. found that CPX weakens the histone demethylase activity of KDM4B by inducing molecular interactions between nickel ions and the KDM4B protein, thus indirectly inhibiting the downstream MYC signaling pathway and mitochondrial oxidative phosphorylation in neuroblastoma, which inhibits the proliferation of neuroblastoma (Yang et al., 2017). The gene discussed is KDM4B; the disease is neuroblastoma.