The mechanism of KDM4B in leukemia is not well defined, and KDM4B expression is downregulated in chronic lymphoid leukemia (CLL) (Filiu-Braga et al., 2019), but KDM4B is known as an oncogene in acute lymphoid leukemia and its expression can be reduced using the spermidine analog Analogue-N 4-erucoyl Spermidine (Filiu-Braga et al., 2019). The gene discussed is KDM4B; the disease is B-cell chronic lymphocytic leukemia.