LCN2 and ovarian cancer: In epithelial ovarian cancer cells, hypoxia leads to upregulation of the KDM4B gene, which reduces H3K9me markers in the promoters of transfer-related genes such as LOXL2, LCN2, and PDGFB, thereby increasing the expression of these genes and ultimately facilitating ovarian cancer cell migration and invasion (Wilson et al., 2017).