In epithelial ovarian cancer cells, hypoxia leads to upregulation of the KDM4B gene, which reduces H3K9me markers in the promoters of transfer-related genes such as LOXL2, LCN2, and PDGFB, thereby increasing the expression of these genes and ultimately facilitating ovarian cancer cell migration and invasion (Wilson et al., 2017). The gene discussed is LCN2; the disease is ovarian carcinoma.