LYN also positively correlated with various immune infiltrating cells, including Tregs, M2 macrophage, and MDSC, which contribute to an immunosuppressive microenvironment in gliomas (Marvel and Gabrilovich, 2015; Zhang et al., 2021d; Zhang et al., 2021e; Zhang et al., 2021f). The gene discussed is LYN; the disease is glioma.