In glioma samples with high LYN expression, oncogenic driver genes such as EGFR (7p11.2) and CDK4 (12q14.1) were frequently amplified, while tumor suppressor gene PTEN (10q23.31) and CDKN2A (9p21.3) were frequently deleted (Figure 4C). The gene discussed is CDK4; the disease is glioma.