The ECM–receptor interaction, p53 signaling pathway, estrogen signaling pathway, PI3K–AKT signaling pathway, regulation of actin cytoskeleton, and drug metabolism–cytochrome P450 were the most enriched pathways in the upregulated genes in the 226 DEGs, indicating a common regulation of tumor microenvironment, cell proliferation, cell division, and drug metabolism by cisplatin and hAECs or EXOs. The gene discussed is TP53; the disease is neoplasm.