We performed RNA sequencing detection on the kidney tissue of C57BL/6J cisplatin-AKI mice, and found that after cisplatin injury and hAECs or EXOs treatment, the TNF pathway was enriched and upregulated in cisplatin-AKI group but downregulated in cisplatin-AKI mice treated with hAECs or EXOs. Here, TNF is linked to acute kidney injury.