Consistent with a previous finding that CK2 promotes Hh signaling by phosphorylating Ci/Gli in addition to Smo (Jia et al., 2010), a recent phosphoproteomics study identified CK2 as critical for the stabilization and transcriptional activity of Gli2 in granule neuron precursors and showed that pharmacological inhibition of CK2 attenuated the growth of Shh-type medulloblastoma cells expressing a drug resistant Smo mutant (Purzner et al., 2018). Here, SMO is linked to medulloblastoma.