Moreover, in vitro functional assays and in vivo tumor models have demonstrated that DUXAP10 is mainly implicated in eliciting the transformation of Cd-exposed (Cd-T) cells to cancer stem cells (CSCs), promoting the cell cycle progression, proliferation, migration, and invasion of A549 or H1975 cells, and thus accelerating tumorigenesis and progression in lung cancer. Here, DUXAP10 is linked to cancer.