Recently, the pseudogene lncRNA DUXAP10 (DUXAP10) (Booth HA, and Holland PW., 2007; Zhu et al., 2018), localized on chromosome 14q11.2, was found to be overexpressed in multiple cancers, including HCC, bladder cancer (BC), non-small-cell lung cancer (NSCLC), glioma, renal cell carcinoma (RCC), papillary thyroid carcinoma (PTC), prostate cancer (PCa), chronic myelogenous leukemia (CML), ovarian cancer (OC), pancreatic cancer (PC), GC, colorectal cancer (CRC), esophageal squamous cell carcinoma (ESCC) and oral squamous cell carcinoma (OSCC). This evidence concerns the gene DUXAP10 and pachyonychia congenita.