Notably, it was found that DUXAP10 (Wu et al., 2021) was involved in facilitating the stem cell-like properties of glioma U251 and T98G cells by increasing the expression of Sox2, CD133, Oct4 stemness markers, the ability of tumorsphere formation, and the activity of ALDH, which closely aligns with the CSC induction mentioned in the above chronic Cd exposure study on lung cancer. This evidence concerns the gene SOX2 and central nervous system cancer.