ALPL and pseudoxanthoma elasticum (inherited or acquired): Current therapeutic interventions to address ectopic mineralization in disorders such as PXE involve a variety of approaches including PPi supplementation (Dedinszki et al., 2017), bisphosphonates (Kranenburg et al., 2018), statins (Guo et al., 2013), TNAP inhibition (Li et al., 2019), and dietary supplementation of magnesium and citrate (LaRusso et al., 2009; Phillips et al., 2015).