After observing that knocking down METTL3 and YTHDF2 decreased lipid accumulation in hepatocellular carcinoma cells, Zhong et al. (2018) proposed that the presence of m6A in mRNA mediates crosstalk between the circadian clock and lipid metabolism (Zhong et al., 2018). This evidence concerns the gene METTL3 and hepatocellular carcinoma.