THY1 and pulmonary fibrosis: Interestingly, fibroblasts show reduced Thy-1 expression in areas of active fibrogenesis in human idiopathic pulmonary fibrosis, and in vitro experiments have shown that the lack of Thy-1 expression in fibroblasts is enough to induce myofibroblast differentiation on soft matrix substrates (Hagood et al., 2005; Fiore et al., 2015; Fiore et al., 2018).