TF and central nervous system cancer: In vitro, MTT assay showed higher cytotoxicity, enhanced cellular uptake, and reduction in tumor accumulation and volume with Tf-PEG-PLA-NPs of resveratrol followed by PEG-PLA-NPs as compared to the free drug in U87 and C6 glioma cells. Prolongation of life expectancy of rats bearing C6 glioma