Hence, the nucleic-acid-based pharmaceutical technology on which the COVID-19 vaccines are based upon elicits potent immune responses via Toll-like receptos (TLR), interleukins (IL) IL-6, IL-12, interferon type 1 (IFN-1), tumour necrosis factor α (TNFα), pattern recognition receptors, dendritic cell maturation, induction of CD4+ and CD8+ T cell responses, among others (16, 17, 38, 41–44). The gene discussed is TNF; the disease is COVID-19.