PF4 and acute disseminated encephalomyelitis: Of particular importance are strong immune-related life-threatening conditions involving antibody-mediated platelet activation in VITT cases (platelet factor 4) (74), neutrophil and histiocyte infiltrates in myocarditis (75), and reactive astrocytes, microglia, and foamy macrophaghes in cases of acute disseminated encephalomyelitis (neuro-inflammation) (76).