Moreover, F. nucleatum infection can increase the secretion of miR-1246/92b-3p/27a-3p and CXCL16/RhoA/IL-8-enriched exosomes from CRC cells, which can enhance the cell migration ability of non-infected CRC cells in vitro and promote CRC metastasis in vivo (Guo et al., 2020). The gene discussed is CXCL8; the disease is colorectal carcinoma.