F. nucleatum infection can upregulate caspase recruitment domain 3 (CARD3) expression by activating autophagy signaling (Chen et al., 2020) and by upregulating KRT7-AS/KRT7 by activating the NF-κB pathway (Chen et al., 2020), which promotes CRC metastasis. The gene discussed is NFKB1; the disease is colorectal carcinoma.