In research on inactivated influenza vaccines, the expression of IL-17 and NF-κB pathway genes and related innate immune activation have been observed (Alcorn et al., 2020); Rubella vaccine significantly affects the host’s antigen presentation and innate/inflammatory genome (Haralambieva et al., 2013); Hantavax vaccine can mediate Th17 cell differentiation, antigen processing and presentation, NF-kappa B signaling pathway, phenylalanine metabolism, phagosome, Fc gamma R-mediated phagocytosis (Khan et al., 2019). The gene discussed is NFKB1; the disease is influenza.