Given that we have yet to identify a scenario in which we can sufficiently deplete only the lung CD4 T-cells in the context of the latent infection, we cannot conclude that the CD4 T-cells are responsible for control of the latent infection, rather our current data support a scenario in which the CD4 and CD8 T-cells work in concert. This evidence concerns the gene CD8A and disease arising from reactivation of latent virus.