STAT3 and central nervous system cancer: The GSEA analysis indicated that MAN2B1 was enriched in the inflammatory response, interferon-alpha response, interferon-gamma response, complement, IL6_JAK-STAT3 signaling, IL2-STAT5 signaling, P53 pathway, apoptosis, coagulation, and allograft rejection, which have been all involved in glioma tumorigenesis and malignant development (29, 30).