The GSEA analysis indicated that MAN2B1 was enriched in the inflammatory response, interferon-alpha response, interferon-gamma response, complement, IL6_JAK-STAT3 signaling, IL2-STAT5 signaling, P53 pathway, apoptosis, coagulation, and allograft rejection, which have been all involved in glioma tumorigenesis and malignant development (29, 30). Here, TP53 is linked to central nervous system cancer.