CASP3 and acute promyelocytic leukemia: In another recent study, MET when combined with EGCG (epigallocatechin-3-gallate, a polyphenol present in green tea), increased the levels of caspase-3 and decreased levels of survivin, thereby significantly promoting apoptosis in HCC cells (49), Additionally, another study showed that the co-treatment of HepG2 cells with ATO (arsenic trioxide, a therapeutic agent used in the treatment of acute promyelocytic leukemia) potentiated the anti-HCC efficacy of ATO and increased apoptosis in vitro by decreasing the levels of Bcl-2 (50).