GP73 (18), osteopontin (OPN) (54), midkine (MDK) (57), annexin A2 (ANXA2) (60), annexin A3 (ANXA3) (64), dickkopf-1 (DKK1) (67), thioredoxin (TRX) (70) and polymerase 1 (PARP1) (72) have shown diagnostic value for the early diagnosis of liver cancer. This evidence concerns the gene SPP1 and liver cancer.