Among 48 patients, 56.3% of patients had at least one mutation of the four sites in the following three genes (c.747 for TP53, c.121, c.133 for CTNNB1 and c.1-124 for TRET), which could be further found in 22.2% of HCC patients’ tissues (22, 23). Here, CTNNB1 is linked to hepatocellular carcinoma.