α-fetoprotein (AFP) (5) and Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3) (6, 7), des-gamma-carboxy prothrombin (DCP) (6) and glypican-3 (GPC3) (8, 9) have been used for the clinical diagnosis of HCC. The gene discussed is ACE; the disease is hepatocellular carcinoma.