The change of Lys48-linked ubiquitination in heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) inhibited HNRNPA1-dependent pyruvate kinase isozyme splicing, and subsequently promoted glucose metabolism reprogramming and malignant behavior of cells in HCC (144). This evidence concerns the gene HNRNPA1 and hepatocellular carcinoma.