Compared to the cohort from 2009-2013, the patients with NBNC-HCC in 2014-2018 were significantly older (p = 0.047) and had a higher BMI (p = 0.002) and higher AFP (p< 0.001), and more frequently had T2DM (p = 0.049), hypertension (p = 0.004) and MAFLD (p = 0.003). This evidence concerns the gene AFP and type 2 diabetes mellitus.