The results showed that TDs remained an independent risk factor for OS after adjusting for baseline factors (age, sex, marital status), stage, other risk factors (CEA, tumor size, tumor differentiation, PNI), treatments (postoperative RT, postoperative chemotherapy), and all the included variables (baseline, stage, treatment, and others), which are all shown in Table 2. The gene discussed is CEACAM5; the disease is neoplasm.