Additionally, M2 macrophages can secrete TGFB2 and activate NFKB1 pathway to regulate FERMT2, forming the TGFB2/NFKB1/FERMT2 axis to promote CRC cells invasion, and NFKB1 inhibitor Bay 11-7082 can reverse functions mentioned above (106, 107). The gene discussed is FERMT2; the disease is colorectal carcinoma.