TP53 and small cell lung carcinoma: Furthermore, in LCNECs, two mutually exclusive genomic subtypes have been identified: one profile shows concurrent TP53 and RB1 mutations similarly to SCLC, whereas the other subtype is predominantly RB1 wild-type and displays concurrent biallelic TP53 and Serine/Threonine Kinase 11 (STK11)/Kelch Like ECH Associated Protein 1 (KEAP1) alterations, similarly to non-SCLC instead (27, 28).