One hundred forty-two differentially expressed proteins were identified (Figure 3A), and further analysis revealed 11 proteins associated with the OS of patients with lung adenocarcinoma: DHX33, DOCK5, DOK1, FAM83D, HYI, IGSF8, MBOAT2, NAA30, RBCK1, SHROOM4 and TNFRSF6B (Figure 3B). This evidence concerns the gene HYI and lung adenocarcinoma.