Moreover, we found for the first time that YTHDF2 could inhibit the migration and invasion of lung adenocarcinoma cells by regulating the epithelial-mesenchymal transition (EMT) through the family with sequence similarity 83D (FAM83D)-TGFβ1-SMAD2/3 pathway. The gene discussed is TGFB1; the disease is lung adenocarcinoma.