CD8+ and FOXP3+ T cells were regularly seen in close proximity of CD34+ MDS/AML, yet not in controls; this finding correlated to blast counts but not to genetics, and the frequencies of immune cell subsets also differed in MDS and sAML when compared to controls, providing novel insights in the dynamics of immune deregulation during MN evolution (163). This evidence concerns the gene CD34 and acute myeloid leukemia.