obtained scRNA-seq profiling of BCR-ABL positive vs negative HSC from patients with chronic myeloid leukemia, and found restricted expression in BCR-ABL negative HSC of inflammatory genes with suppressor functions on HSC (i.e., IL6 and its downstream mediators, TGF-β and TNF-α pathways) (176). This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.