In addition, an EZH2-high tumor was associated with the presence of prominent nuclear pleomorphism, intermediate or high histological risk group, carcinoma ex PA, higher Ki-67 LI and the aberrant expression of p53 in comparison to an EZH2-low tumor (P < 0.001, = 0.015, = 0.014, < 0.001 and = 0.005, respectively). This evidence concerns the gene EZH2 and neoplasm.