The has-miR-200a-5p as an overexpressed molecule is a sensitive biomarker and could be combined with immunohistochemical markers such as TPO, CD56, Galectin 3, MC, CK19, and BRAF both to detect and to distinguish between PTC and benign thyroid tumor with papillary hyperplasia (52). The gene discussed is LGALS3; the disease is hyperplasia.