MiR-222 directly targets the 3′-UTR of PPP2R2A, which expresses the Protein Phosphatase 2 Regulatory Subunit B Alpha (PPP2R2A), a tumor suppressor, altering the Akt signaling pathway, and therefore enhancing the tumor metastasis in nude mice (36, 37). Here, PPP2R2A is linked to neoplasm.