IRS2 and metastatic neoplasm: Via the Akt pathway and by targeting the expression of ARFGEF1 and IRS2 genes, respectively, miR-215 and miR-766 detected in lower levels promoted lymph node metastasis, while miR-431 was suppressed in lymph node metastasis, accounting for an important biomarker for metastatic disease, regulating cytoskeleton formation by E-cadherin and Vimentin, and inhibiting the Hedgehog pathway (83–85).