Upregulation of miR-221 possibly through interleukin 17 and miR-222 is correlated with the advanced TNM stage, capsular invasion, extrathyroidal extension, and lymph node metastasis, a fact that is also included in American Thyroid Association risk factors guidelines (22, 33, 34). The gene discussed is IL17A; the disease is metastatic malignant neoplasm in the lymph nodes.