Similarly, Schirmer et al. [7] analyzed PR3-ANCA positive granulomatosis with polyangiitis (GPA), myeloperoxidase (MPO)-positive GPA, and MPO-ANCA positive MPA and found that increased relapse rate was observed among patients with PR3-ANCA irrespective diagnosis. This evidence concerns the gene PRTN3 and granulomatosis with polyangiitis.