Moreover, miR-128-3p limits metastasis and EMT in esophageal squamous cell cancer (ESCC) by targeting zinc finger E-box binding homeobox factor 1 (ZEB1) (Zhao et al., 2018), which is known as the EMT activator and a key factor in promoting metastasis in PC (Krebs et al., 2017). This evidence concerns the gene ZEB1 and pachyonychia congenita.