NR3C2 and pachyonychia congenita: The dual regulatory effect of multiple miRNAs on PC has been extensively reported, such as the inhibitory effect of miR-203a-3p on the proliferation, EMT, and apoptosis of PC cells via SLUG (An & Zheng, 2020) and the promotional effect of miR-135-5p on the migration, invasion, and EMT of PC cells by targeting NR3C2 (Zhang et al., 2017b).