FGF-21 was independently associated with an increased cfPWV (per 10 pg/mL, odds ratio (OR): 1.008; 95% confidence interval (CI): 1.003–1.012; P=0.001) after adjusting for other factors associated with increased cfPWV identified from Table 1 (DM, hypertension, age, CRP, and body weight). The gene discussed is CRP; the disease is Hypertension.