Assignment was done to those factors (Table 8), and logistic regression analysis was performed to analyze whether those factors were independent risk factors for the onset of COPD-PH, and it turned out that elevation of hs-CRP (OR: 2.314, 95% CI: 1.104–4.211), IL-6 (OR: 2.564, 95% CI: 1.114–4.789), and ET-1 (OR: 3.759, 95% CI: 1.229–5.116) and decrease of IL-10 (OR: 6.151, 95% CI: 3.119–5.243) were all independent risk factors for the onset of COPD-PH. The gene discussed is EDN1; the disease is chronic obstructive pulmonary disease.