CCL2 and steatosis: In another study, it was reported that PD treatment for 4 weeks can remarkably reduce Gr-1+ cells and alleviate hepatocyte steatosis and decrease expressions of proinflammatory factors including S100A8, S100A9, and monocyte chemoattractant protein-1 (MCP-1) in the liver tissues of HFD mice [60, 61].