TGFB1 and Hepatic fibrosis: The activated KCs constitute a central component of the inflammatory response in liver fibrosis by producing amount proinflammatory cytokines such as MCP-1, TNF-α, and TGF-β1 and mediators related to oxidative stress that induce quiescent HSCs to differentiate into activated myofibroblasts, the principle ECM-synthesizing cells which play as the vital executor in hepatic fibrogenesis.