Meanwhile, research shows that Acylglycerol kinase (AGK), a newly discovered lipid kinase, could increase the nuclear accumulation of β-catenin by activating the PI3K/AKT/GSK-3β signaling pathway in renal cell carcinoma (RCC) that further potentiates the activity of TCF/LEF transcription factor [31]. The gene discussed is GSK3B; the disease is hereditary clear cell renal cell carcinoma.