FHL2 and dry eye syndrome: To gain more insight about the roles of sPmel17-FHL2 in KCs treated with MC-CM, we designed shRNA vectors targeting the Pmel17 gene in MCs (Figure 4(a), S1) and examined the effects of the CM from MCs transfected with the Pmel17 shRNA lentiviral vector (MC-CM/shPmel17) on the expression levels of FHL2 and E-cad as well as the cytoskeletal F-actin pattern in KCs, using a shRNA scramble plasmid as a negative control.