CD79A and selective IgA deficiency disease: For instance, HLA-A∗01 and HLA-B∗14 alleles were associated with an increased IgAD risk and carriers resulted to have a significantly lower mean serum IgA concentration; conversely, HLA alleles B∗07 and DRB1∗15 were found to confer protection against SIgAD and, accordingly, carriers showed a significantly increased mean serum IgA concentration [47].