However, such an HLA immunogenetic predisposition to CD is quite common in the general population (since 30%–40% of the individuals in Europe, North America, and other populations have been demonstrated to carry HLA-DQB1∗02 alleles) and, thus, it is not sufficient for developing CD: indeed, only a minority of these MHC DQ2/DQ8 carriers (around 3%) actually develop CD during life, despite a comparable dietary exposure to gluten [62–64]. The gene discussed is HLA-C; the disease is Cowden disease.