APLN and hypertrophic cardiomyopathy: On the other hand, the “histidine metabolism,” “cardiac muscle contraction,” “hypertrophic cardiomyopathy (HCM),” “insulin resistance,” “leukocyte transendothelial migration,” and “Apelin signaling pathway” pathways were enriched (P value = 0.0086, 0.0325, 0.0332, 0.04, 0.042, and 0.049, respectively, and Figure 5(e) and Table 4).