ACLY and neoplasm: De novo lipogenesis provides intermediate materials to support the phospholipid and triglyceride synthesis, lipid modification of proteins, and fatty acid ß-oxidation in tumor cells, including fatty acid synthase (FAS), stearoyl CoA desaturase 1 (SCD1), adenosine triphosphate-binding cassette family (ABC family), ATP citrate lyase (ACLY), and fatty acids and thus augments the activation of growth-promoting pathways [23].