TNF and neoplasm: For instance, genes involved in NF-kappa B pathway and TNF signaling, such as overexpression of BCL2 regulator of mitochondrial apoptotic pathway (Tsuyama et al., 2017), BCL6 proto-oncogene, essential for GC development and FBXO11 a tumor-suppressor gene that stabilizes BCL6, have already been related with DLBCL accelerated development and poor prognosis (Saito et al., 2007; Duan et al., 2012; Zhang et al., 2015).