We found that these 21 hsa-mir-31–related TFs were highly consistent with colon cancer–related TFs, such as APC, ARID1A, MCM2, MYC, TCF3, TP53, SP1, and TOP1, which were collected from DisGeNET (Piñero et al., 2017) and PTMD (Xu et al., 2018). The gene discussed is TOP1; the disease is malignant colon neoplasm.