We found that these 21 hsa-mir-31–related TFs were highly consistent with colon cancer–related TFs, such as APC, ARID1A, MCM2, MYC, TCF3, TP53, SP1, and TOP1, which were collected from DisGeNET (Piñero et al., 2017) and PTMD (Xu et al., 2018). This evidence concerns the gene TOP1 and colonic neoplasm.