The predicted top five lncRNAs are MALAT1, MEG3, BCYRN1, UCA1, and LSINCT5, among which MALAT1 and MEG3 are found to be associated with esophageal squamous-cell carcinoma in lncRNADisease in 2017. The gene discussed is MALAT1; the disease is esophageal squamous cell carcinoma.