In a tissue microarray cohort, Li et al. (2020) found that low expression of m6A regulators including METTL3, METTL14, and YTHDF2 predicted poor prognosis of osteosarcoma patients, while low expression of KIAA1429 and HNRNPA2B1 correlated with longer overall survival time. This evidence concerns the gene METTL3 and osteosarcoma.