VPS11 (β = −0.25, SE = 0.03, p = 6.0 × 10−15) demonstrated the opposite direction of effect in all tissue except skeletal muscle and the left ventricle of the heart, meaning increased VPS11 expression in skeletal muscle and left ventricle is associated with increased PAD, CAD, and smoking risk. This evidence concerns the gene VPS11 and peripheral arterial disease.