The direction of effect in all tissue was opposite to the direction of effect for PAD and CAD: the allele associated with increased VDAC2 expression (EA = C, EAF = 0.57) is associated with decreased PAD and CAD (β = −0.14, SE = 0.02, p = 7.7 × 10−9). Here, VDAC2 is linked to coronary artery disorder.