This variant mapped to the nearby gene PNPLA3, a well-established locus associated for non-alcoholic fatty liver disease (Speliotes et al., 2011), multiple liver enzymes measures (Yuan et al., 2008), hemotological traits (Kamatani et al., 2010), sex-hormone binding globulin levels (Ruth et al., 2020), and T2D (Mahajan et al., 2018). Here, SHBG is linked to metabolic dysfunction-associated steatotic liver disease.