To the best of our knowledge, this case is the first prenatal diagnosis of TALDO deficiency in a Chinese population (Verhoeven et al., 2001; Eyaid et al., 2013; Rodan and Berry, 2017; Lee-Barber et al., 2019; Williams et al., 2019; Halabi et al., 2019; Lafci et al., 2021). The gene discussed is TALDO1; the disease is hyperinsulinemic hypoglycemia, familial, 4.