In pathological contexts, LLT1 has been reported to be expressed on EBV and HIV-infected B cells (27), Dengue virus-infected CD14+CD16- myeloid cells (34), hepatitis B virus-infected liver in correlation with viral replication (35), RSV-infected lung epithelial cells (36), monocytes of synovial fluid and macrophages within synovial tissue of patients with rheumatoid arthritis (16). This evidence concerns the gene CLEC2D and rheumatoid arthritis.